Brunold Research Group

Welcome to the Brunold Lab!

Metal Centers in Proteins and Cofactors

Research in the Brunold Lab integrates spectroscopy and computational chemistry to investigate metal-containing proteins and cofactors. Various spectroscopic techniques are employed to probe the ground state (resonance Raman, electron paramagnetic resonance spectroscopy) and excited states (electronic absorption, magnetic circular dichroism) of the metal centers, and are combined with electronic structure calculations (density functional theory (DFT), time-dependent DFT,  quantum mechanics/molecular mechanics). Together, these spectroscopic and computational methods provide insight into the structure and mechanism of metal-dependent proteins.